With Miami trailing by five runs after seven innings, Stanton was replaced in the eighth inning. He had an X-ray taken on his foot and ankle, and it came back negative.
Stanton's status is day-to-day, but it is likely he will be given Sunday's series finale with the Nationals off.
Stanton initially rolled his right ankle while stepping on first base last Sunday at Atlanta in Miami's 7-0 win over the Braves at Turner Field. He has played through some discomfort this past week.
"It was just one of those days," Stanton said. "Today, it hurt, I don't know why, more than almost the first day that it happened."
There was not a specific play or moment that led to more intensified discomfort.
"A bunch of factors could have gone into it," he said. "I'm just calling it a bad day, right now."
Stanton is dealing with discomfort to both sides of his ankle, as well as his heel.
Justin Ruggiano moved from center field to right field to replace Stanton in the eighth inning, and rookie Jake Marisnick played center.
Stanton was hitless in three at-bats on Saturday, and he is batting .249 on the season with 19 homers and 46 RBIs.
Joe Frisaro is a reporter for MLB.com. He writes a blog, called The Fish Pond. Follow him on Twitter