Since being obtained by Miami from Houston on July 4, the veteran first baseman has anchored first base, appearing in 64 games.
But in the fifth inning on Friday night, Lee was shaken up on a slide into second base, and he was removed from the game with a neck strain.
However, Lee shouldn't miss any time.
"Carlos is fine," manager Ozzie Guillen said after Miami's 4-0 victory. "Right after the game, he told me he was fine, and he should be ready for [Saturday's] game."
Lee delivered a two-out, RBI single off Cincinnati's Bronson Arroyo in the fifth. On the play, there was confusion, a couple of runs scored and Lee was caught in a rundown.
Justin Ruggiano and Jose Reyes, who each singled with one out, ended up scoring. Lee was credited with an RBI when Ruggiano scored from second.
Right fielder Jay Bruce's throw to the plate was too late to get Ruggiano. Lee was caught between first and second, and he was in a rundown. Reyes, meanwhile, dashed for home, and the throw home was not in time.
Still, the Reds were able to throw out Lee attempting to slide into second base. On the play, Lee attempted a headfirst slide, and he was tagged out by Wilson Valdez.
Lee remained on the ground for a few minutes, and was tended to by assistant trainer Mike Kozak and manager Ozzie Guillen.
Greg Dobbs shifted from third base to first base, and Gil Velazquez played third base.