On Wednesday, Major League Baseball released its schedule for 2013, a season in which the Marlins will look to bounce back from a disappointing '12 campaign.
A week after their opener, the Marlins kick off their second season at Marlins Park, starting a nine-game homestand against the Atlanta Braves.
Following 19 games against National League opponents, including 15 against NL East division foes, Miami beings Interleague Play with a two-game series against the Minnesota Twins from April 22-23 at Target Field.
But it's the Marlins' second Interleague series that will present the most intrigue. On May 24, Ozzie Guillen will return to Chicago to face the White Sox for the first time. Guillen played for the White Sox and managed them to a World Series Championship in 2005.
The Dodgers come to town Aug. 19-22 for a four-game series, meaning Hanley Ramirez will return to Miami once again.
Other Interleague series for the Marlins include a home-and-home set against the Tampa Bay Rays from May 27-30. The first two games will be played at Tropicana Field, and the latter two at Marlins Park.
From Aug. 2-4, the Marlins will host the Cleveland Indians. They will travel to Kansas City for a three-game series starting Aug. 12.
Following a stretch of 15 road games in a 22-game span, the Marlins return home to finish out their season with what could be a tough test. After a three-game set against the Philadelphia Phillies, they finish the season with an Interleague series against the Detroit Tigers from Sept. 27-29 at Marlins Park.
Jake Kaplan is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.