"It's over," Reyes said. "I have an opportunity to start a new one tomorrow. I have to give some credit to Dickey. He was unbelievable. It's not easy to face Dickey. I'll take a 26-game hitting streak any day. It was a good run."
The streak matched the second longest in Marlins history. A year ago, Emilio Bonifacio hit safely in 26 games. The club record is 35, set by Luis Castillo in 2002.
"Very sad day overall," manager Ozzie Guillen said. "Jose, he had a great run. Hopefully he makes another one happen pretty soon. I think this kid has been playing great.
"Obviously, we were pulling for him for that. But in the meanwhile, it was great to see what he was doing during that streak."
At a point in the season where the Marlins are scrambling to regain credibility and establish a winning culture, Reyes is taking on extra responsibility.
The four-time All-Star shortstop told Guillen before Wednesday's game that having missed so much time due to injuries in the past made him want to play through a swollen right hand.
"Jose loves to play," Guillen said previously. "I think on this ballclub, a lot of people look up to him. I expect him to be the guy to be out there to lead this ballclub the right way. He is doing everything we ask him to do."
Reyes sustained the ailment last Friday in Washington, when he was jammed on a pitch by Gio Gonzalez. He continues to experience swelling between his thumb and index finger.
It hurts Reyes more batting from the right side, and he feels it less from the left. And his home run, which landed in the second deck in right field, came batting left-handed against right-hander Chris Young.
"It was a good pitch to hit," Reyes said. "I was able to put a good swing on that ball."
The 26-game hit streak was the longest by a reigning batting champion since Joe DiMaggio's MLB-record 56-game string in 1941.
Reyes started his streak on July 13, the first game after the All-Star break. In the 26 games, he hit .358 (38-for-108) with five home runs, eight doubles and two triples. His on-base percentage was .405 in the stretch.