For a couple of months, they've struck the Marlins hard.
"It's the game. We know it's the game," general manager Michael Hill said. "You always know going into a year, you're going to have to absorb injuries, you're going to have to absorb adversity, whatever the adversity is. You have to absorb it to get to wherever you want to go."
The latest tough break was losing Emilio Bonifacio, placed on the disabled list on Saturday after spraining his left thumb on Friday.
An X-ray came back negative, but more will be known on Bonifacio's recovery after he is evaluated on Monday in Miami by team physicians.
Although Bonifacio has been playing second base since Omar Infante was traded to Detroit, he opened the season in center field.
Now all three of Miami's Opening Day outfielders are on the disabled list. Giancarlo Stanton had surgery on his right knee on July 8, and he is expected to return on Tuesday in New York. Logan Morrison went on the DL on July 29 with right knee inflammation. He may need season-ending surgery.
The string of injuries has prevented the team from developing continuity. When Miami acquired Carlos Lee from the Astros on July 4, they hoped he would help solidify the heart of the order.
"We make a trade for Lee, and Stanton has to go on the DL because of his knee," Hill said. "You're on the brink of getting Stanton back, and Boni makes a dive and re-injures his thumb."
The Marlins have slipped out of contention, but Hill says the goal has remained the same.
"The bottom line is you're still trying to win baseball games," Hill said. "That's still the goal."
The final two months are crucial because players are being evaluated for the future.
"There are players that are in different parts of their careers," Hill said. "They're playing to establish themselves, show whatever they want to show. But the bottom line is, you're still trying to win baseball games."