The Marlins came into the two-game series at Tuner Field with a 3-8 record against the rest of the NL East, including a seven-game losing streak away from home after an opening road win.
The Marlins spoiled the Phillies' home opener, winning, 6-2, on April 9. But they dropped the next two games in Philadelphia before being swept in New York and going 0-2 with a rainout in Washington.
The only bright spot for Miami against division rivals was taking two of three against the Mets at home last weekend.
The Marlins have won just one season series in Atlanta in the past 14 years, going 6-3 at Turner Field in 2009. They were 4-5 last year and 2-7 in 2010, posting 6-12 and 7-11 overall records against the Braves in those seasons.
The Braves, who have won all except three of the past 14 overall season series against the Marlins, make their first trip to Marlins Park in Miami for a series June 5-7.
"To be the best, you've got to beat the best," Marlins manager Ozzie Guillen said. "We've got to step it up a notch."