Prado suffered a right hamstring strain Wednesday playing for Venezuela in the World Baseball Classic. An MRI was taken Saturday, and more information on his status is expected Sunday.
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On Saturday, Dietrich played third base and was hitless in two at-bats, and was hit by a pitch in the Marlins' 5-4 loss to the Tigers at Publix Field.
"It's tough if you lose [Prado] for some time," Dietrich said. "He's one of our leaders. He will be here in spirit, and hopefully get him back on the field as quickly as possible. We've got a good group of position players."
Manager Don Mattingly has said Dietrich and Miguel Rojas will get the majority of work at third.
Handling a number of roles is nothing new for Dietrich, who has played second base, third, first and left field.
"For me, nothing has really changed," Dietrich said. "Business as usual, like I have been the last few seasons with the ballclub. Just be available to play multiple positions, wherever Donnie puts my name in the lineup."
A left-handed hitter with power, Dietrich batted .279 with a .374 on-base percentage in 2016. He belted seven home runs and drove in 42.
"Myself and Miggy can handle multiple positions, and put together good at-bats," Dietrich said. "I'm sure they're going to lean on us, and we'll be ready to go."
Joe Frisaro has covered the Marlins for MLB.com since 2002. Follow him on Twitter @JoeFrisaro and listen to his podcast. This story was not subject to the approval of Major League Baseball or its clubs.